"Growth dynamics of meningiomas in patients with multiple sclerosis
treated with interferon: report of two cases"
Batay F, Al-Mefty O.
Department of Neurosurgery, University of Arkansas for Medical
Sciences, Little Rock, Arkansas, USA.
BACKGROUND: Although multiple sclerosis (MS) is a common
disease of the central nervous system, the association of
intraparenchymal tumour has been rarely reported and the potential
relationship between intracranial meningioma and MS has not been
seriously analysed.
This report addresses the association of multiple sclerosis and
intracranial meningioma and discusses the effect of interferon
treatment on tumour progression.
CLINICAL PRESENTATION: We report two cases with multiple
sclerosis, who developed meningioma four and twenty years after the
diagnosis of MS was made. Neither patient had a history of
meningioma initially and both were being treated interferon when the
meningioma was progressed.
FINDINGS: Histological examination of two cases revealed
meningothelial meningioma. The first patient's KI67 level was 2.5%
and was positive for the progesterone and estrogen receptor.
Chromosomal analysis showed some abnormalities. In the second case,
mild atypical change by presence of nuclear enlargement and rare
mitotic figures were noted and PCNA, KI67 levels were less than 2%.
CONCLUSIONS: We reported the association of multiple
sclerosis and intracranial meningioma and observed the progression
of the meningiomas during interferon treatment. Although, we cannot
exclude the coincidence between the two diseases we discussed
suspicious relationship between the interferon treatment and the
tumour progression.
Acta Neurochir (Wien) 2002 Apr;144(4):365-8
PMID: 12021883 [PubMed
Link]
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