| Hepatic injury (liver damage) including elevated serum hepatic
enzyme levels and hepatitis, some of which have been severe, has been
reported.
In some patients a recurrence of elevated serum (blood) levels of
hepatic enzymes have occurred upon Avonex ® rechallenge.
In some cases, these events have occurred in the presence of other
drugs that have been associated with hepatic injury.
The potential of additive effects from multiple drugs or other hepatotoxic
agents (liver damaging substance; e.g., alcohol) has not been determined.
Rare cases of autoimmune hepatitis
(inflammation of the liver caused by the body's immune system attacking
it) have also been reported in patients using interferons.
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