| No studies were conducted to evaluate the effects of Avonex
® on fertility in normal women or women with multiple sclerosis.
No studies have been done in either animals or humans to determine
the effect of Avonex on reproductive capacity. It is therefore, not
known whether Avonex ® can affect human reproductive capacity.
Animal studies have been performed to determine the teratogenic effects
(abnormal development or malformations)
on the growing fetus. None were observed.
At doses several hundred times the human equivalent,
abortifacient† activity
was observed in animals. It is not known whether these results can safely
be extrapolated to humans.
There are no adequate studies or data on
pregnancy and use of interferons in women.
Pregnant women should be advised that there
may be a risk of potential hazard to the fetus should interferon therapy
be continued. Discontinuation of therapy is advised.
† abortifacient -
a substance that causes pregnancy to end prematurely and cause abortion.
|
